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Clear cell renal cell carcinoma ( ccRCC ) is well known for its hypervascularity due to the Von Hippel-Lindau/hypoxia-inducible factor dysregulation. Recent findings suggested that copper transporte ...


Top-line results from the CABOSUN randomized phase 2 trial of Cabozantinib ( Cabometyx; Cometriq ) in patients with previously untreated advanced renal cell carcinoma ( RCC ) were announced. The tria ...


Lenvatinib mesylate ( Lenvima ) is an orally administered multiple receptor tyrosine kinase ( RTK ) inhibitor with a novel binding mode that selectively inhibits the kinase activities of vascular endo ...


Pulmonary arterial hypertension ( PAH ) is a major complication in renal failure patients, but very little information is available on the cardiovascular parameters in these patients. The prevalence ...


The FDA ( Food and Drug Administration ) has required labeling changes regarding the recommendations for Metformin-containing medicines for diabetes to expand Metformin’s use in certain patients with ...


Death in dialysis patients results mainly from cardiovascular and cerebrovascular diseases. No prospective study has compared the rates of mortality or cardiovascular events between patients with and ...


The aim of a study was to compare survival of resected and unresected patients in a large cohort of patients with metastases to the pancreas from renal cell carcinoma ( PM-RCC ). Data from 16 Itali ...


Patients with metastatic renal cell carcinoma ( mRCC ) received Sunitinib ( Sutent ) in a global expanded-access program ( EAP ). Researchers have reported the efficacy and safety results for the ...


Aim of a study was to investigate for the presence of existing prognostic factors in patients with bone metastases ( BMs ) from renal cell carcinoma ( RCC ) since bone represents an unfavorable site o ...


Nivolumab ( Opdivo ), an anti-PD-1 immune checkpoint inhibitor, significantly prolongs survival in patients with advanced kidney cancer, whose disease has progressed after their first treatment, accor ...


Although assessment of cardiovascular safety is mandated by regulatory agencies for the development of new drugs to treat type 2 diabetes mellitus, evaluation of their renal safety has been relatively ...


Limited prospective data are available on the long-term safety of Darbepoetin alfa ( Aranesp ) for treating anemia in children with chronic kidney disease ( CKD ). In this prospective, phase IV, ob ...


Safety concerns with erythropoietin analogues and intravenous ( IV ) iron for treatment of anemia in chronic kidney disease ( CKD ) necessitate development of safer therapies. Roxadustat ( FG-4592 ...


The TEMPO 3:4 Trial results suggested that Tolvaptan ( Samsca ) had no effect compared with placebo on albuminuria in autosomal-dominant polycystic kidney disease ( ADPKD ) patients. However, the use ...


The association between apparent treatment resistant hypertension ( ATRH ) and clinical outcomes is not well studied in chronic kidney disease. Researchers have analyzed data on 3367 hypertensive ...


Periodontitis may add to the systemic inflammatory burden in individuals with chronic kidney disease ( CKD ), thereby contributing to an increased morality rate. A study aimed to determine the assoc ...


Cytomegalovirus ( CMV ) is a risk factor for patient and graft survival after kidney transplantation. Researchers at University Transplantation-Center ( UTC ), Hamburg ( Germany ), retrospectively ...


The efficacy of de novo Everolimus ( Certican ) with reduced-exposure calcineurin inhibitor ( CNI ) was examined in kidney transplant subpopulations from the A2309 study that were identified to be at ...


Vascular calcifications and fractures are major complications of chronic kidney disease. Hemodialysis patients have a high prevalence of atrial fibrillation and an increased risk of thromboembolism, w ...


A study has assessed the effect of Pentoxifylline [ Trental ] on proteinuria and renal function in chronic kidney disease ( CKD ) treatment. Researchers systematically searched randomized and non- ...


Children with unilateral Wilms tumor ( WT ) treated with chemotherapy and/or radiotherapy and nephrectomy have excellent survival rates. A solitary functioning kidney is associated with progressive ...


Metanephric neoplasms of the kidney are uncommon, and some cases are associated with papillary carcinoma. Most cases of metanephric adenoma occur in adults, with fewer than 25 cases reported in childr ...


It is known that many medical adverse events can be caused by nonsteroidal anti-inflammatory drugs ( NSAIDs ); however, epidemiologic evidence has not granted an affirmative relationship between NSAID ...


Whether there is a kidney function threshold to statin effectiveness in patients with acute myocardial infarction is poorly understood. A study sought to help fill this gap in clinical knowledge. ...


Edoxaban ( Lixiana, Savaysa ) is an oral, direct, once-daily, factor Xa inhibitor developed for stroke prevention in patients with atrial fibrillation and for the treatment and secondary prevention of ...


While Darbepoetin alfa ( Aranesp ) can be administered once monthly ( QM ) to maintain haemoglobin ( Hb ) concentrations in anaemic patients with chronic kidney disease not on dialysis ( CKD-ND ), the ...


Patients undergoing primary percutaneous coronary intervention ( PCI ) are at high risk for contrast-induced nephropathy ( CIN ), a complication that has been demonstrated to negatively affect outcome ...


Using two drugs was no more effective than a single drug in slowing disease progression in people with autosomal dominant polycystic kidney disease ( ADPKD ). One of the studies also showed that rig ...


Idiopathic membranous nephropathy is an autoimmune disease. In approximately 70% of patients, it is associated with autoantibodies against the phospholipase A2 receptor 1 ( PLA2R1 ). Antigenic targets ...


Hypertension is common in autosomal dominant polycystic kidney disease ( ADPKD ) and is associated with increased total kidney volume, activation of the renin–angiotensin–aldosterone system, and progr ...


Oral anticoagulation therapy ( OAT ) is the choice treatment for thromboembolism prevention in atrial fibrillation ( AF ), although data about oral anticoagulants use in haemodialysis ( HD ) patients ...


Abnormal mineral metabolism is a hallmark in patients with advanced chronic kidney disease ( CKD ). Hyperphosphatemia, and the homeostatic mechanisms controlling phosphate metabolism, have received pa ...


Fibroblast growth factor 23 ( FGF23 ) and Klotho are associated with vascular calcification and cardiovascular disease in dialysis patients. Sevelamer ( Renagel, Renvela ) has been shown to reduce p ...


Serum Alkaline phosphatase ( ALP ) & phosphate are considered to be indicators of vascular calcification. Link between bone metabolism, vascular calcification, cardiovascular events have been well ...


A study has assessed the effects and safety of iron-based phosphate binders in adult patients receiving dialysis. Eight studies with 2018 participants were eligible for the meta-analysis. Iron- ...


The concept of chronic kidney disease - mineral bone disorder ( CKD-MBD ) does not appear to fulfil the requirements for a syndrome at first glance, but its definition has brought some clear-cut benef ...


Reduction of dietary sodium intake or diuretic treatment increases renin-angiotensin-aldosterone system ( RAAS ) blockade efficacy in non-diabetic nephropathy. A study has investigated the effect of ...


Risk of end-stage renal disease ( ESRD ) in kidney donors has been compared with risk faced by the general population, but the general population represents an unscreened, high-risk comparator. A co ...


Peritoneal dialysis is the renal replacement therapy of choice for acute kidney injury in neonates, but in some cases is not feasible or effective. Continuous renal replacement therapy ( CRRT ) machin ...


The two largest studies of mammalian target of rapamycin inhibitor treatment of autosomal dominant polycystic kidney disease ( ADPKD ) have demonstrated no clear benefit on the primary endpoint of tot ...


In phase 4 IMPACT-SHPT study, efficacy and safety of Paricalcitol-centred therapy were compared with that of Cinacalcet-centred therapy for the treatment of chronic kidney disease (CKD)-associated sec ...


In autosomal dominant polycystic kidney disease ( ADPKD ), progressive kidney cyst formation commonly leads to end-stage renal disease ( ESRD ). Because important manifestations of ADPKD may be evid ...


The role of hyperuricemia in disease progression of autosomal dominant polycystic kidney disease ( ADPKD ) has not been defined well. Researchers have investigated the association of serum uric acid ...


Autosomal dominant polycystic kidney disease ( ADPKD ) is a major cause of end-stage kidney failure, but is often identified early and therefore amenable to timely treatment. Interventions known to ...


New-onset diabetes after transplantation ( NODAT ) is a common complication after renal transplantation. There are limited available oral drugs to treat hyperglycaemia in this population owing to redu ...


Atherosclerotic renal-artery stenosis is a common problem in the elderly. Despite two randomized trials that did not show a benefit of renal-artery stenting with respect to kidney function, the useful ...


Abdominal aortic calcification ( AAC ) is reported as a predictor for cardiovascular events in general population and in hemodialysis patients. At present, there are no AAC data in peritoneal dialysis ...


Metanephric adenoma is a rare renal neoplasm, accounting for 0.2% of adult renal epithelial neoplasms. It is usually benign and was first described by Brisigotti et al [ Histol Histopathol 1992 Oct;7( ...


Hyperphosphataemia is a known independent risk factor for cardiovascular mortality. The objective of the study was to compare the effects of two phosphate binders, Sevelamer carbonate ( Renvela ) and ...


Tolvaptan ( Samsca ), a diuretic with a new mechanism of action, selectively binds to the vasopressin V2 receptor and inhibits reabsorption of water. Its effect on heart failure is proven, but its ben ...