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Peritoneal dialysis is the renal replacement therapy of choice for acute kidney injury in neonates, but in some cases is not feasible or effective. Continuous renal replacement therapy ( CRRT ) machin ...


The two largest studies of mammalian target of rapamycin inhibitor treatment of autosomal dominant polycystic kidney disease ( ADPKD ) have demonstrated no clear benefit on the primary endpoint of tot ...


In phase 4 IMPACT-SHPT study, efficacy and safety of Paricalcitol-centred therapy were compared with that of Cinacalcet-centred therapy for the treatment of chronic kidney disease (CKD)-associated sec ...


In autosomal dominant polycystic kidney disease ( ADPKD ), progressive kidney cyst formation commonly leads to end-stage renal disease ( ESRD ). Because important manifestations of ADPKD may be evid ...


The role of hyperuricemia in disease progression of autosomal dominant polycystic kidney disease ( ADPKD ) has not been defined well. Researchers have investigated the association of serum uric acid ...


Autosomal dominant polycystic kidney disease ( ADPKD ) is a major cause of end-stage kidney failure, but is often identified early and therefore amenable to timely treatment. Interventions known to ...


New-onset diabetes after transplantation ( NODAT ) is a common complication after renal transplantation. There are limited available oral drugs to treat hyperglycaemia in this population owing to redu ...


Atherosclerotic renal-artery stenosis is a common problem in the elderly. Despite two randomized trials that did not show a benefit of renal-artery stenting with respect to kidney function, the useful ...


Abdominal aortic calcification ( AAC ) is reported as a predictor for cardiovascular events in general population and in hemodialysis patients. At present, there are no AAC data in peritoneal dialysis ...


Metanephric adenoma is a rare renal neoplasm, accounting for 0.2% of adult renal epithelial neoplasms. It is usually benign and was first described by Brisigotti et al [ Histol Histopathol 1992 Oct;7( ...


Hyperphosphataemia is a known independent risk factor for cardiovascular mortality. The objective of the study was to compare the effects of two phosphate binders, Sevelamer carbonate ( Renvela ) and ...


Tolvaptan ( Samsca ), a diuretic with a new mechanism of action, selectively binds to the vasopressin V2 receptor and inhibits reabsorption of water. Its effect on heart failure is proven, but its ben ...


Tolvaptan ( Samsca ), a diuretic with a new mechanism of action, selectively binds to the vasopressin V2 receptor and inhibits reabsorption of water. Its effect on heart failure is proven, but its ben ...


Endothelial dysfunction underlies multiple cardiovascular consequences of chronic kidney disease ( CKD ) and antecedent diabetes or hypertension. Endothelial insults in chronic kidney disease or end-s ...


Contrast-induced nephropathy ( CIN ) is a frequent complication of many radiological procedures involving the application of contrast media. It represents a significant health problem that causes the ...